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KMID : 0941819920020010011
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Korean Journal of Clinical Pharmacy
1992 Volume.2 No. 1 p.11 ~ p.22
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Antitumor and Immunological Effects of Bovine Thymic Extract
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Abstract
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Thymic extract showed antitumor effect to sarcoma mice with higher dose(200{mu}g/mouse/day i.p., 4weeks) but not with low dose(5{mu}g/mouse/day i.p., 6 weeks). Direct cytotoxicities were exhibited against sarcoma 180, L1210 and MOLT-4 by MTT assay. The spleen weight of mice were increased but the number of circulating lymphocytes were not increased after long-term(2 weeks) administration of thymic extract. Evaluating the mitogenesis by MTT assay. % absorbance of human lymphocytes was not increased by thymic extract. Cell cycle statistics of S phase and G_2/M phase was not increased in the presence of that by PI staining. The formation of rosette was induced, irrespectively of exposure time short-term(l hour) and long-term(2 weeks). The population of mouse blood T-cell to bind Lyt2-antimonoclonal antibody and to L_2T_4 were increased after administration of thymic extract(2-200{mu}g/mouse/day). From the above results, it is suggested that thymic extract exerts antitumor activity by stimulating T cells to differeniate in vivo but not in vitro.
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KEYWORD
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